The RAC rescue helicopter is in attendance at a crash between a car and a tree on Morangup Road in Morangup.
Police and the Department of Fire and Emergency Services were called to the incident at 2.20pm on Tuesday where a car was on fire.
Five DFES crews attended throughout the incident and extinguished the fire by 3.13pm.
Two crews from Midland Fire and Rescue are still on the scene.
Police media said it is believed one occupant has serious injuries.